Research

A major goal of CHLN remains our focus on increasing our NIH and other federal funding. We continued to grow in 2019 as documented by the metrics below. We have focused many of our efforts on several key junior faculty who we believe are soon to convert to NIH R01 PI funding, and this year made very exciting progress on that goal. Our associate director and scientific directors meet monthly with the director to generate ideas on
how to improve the research environment and research productivity at CHLN. In 2020 we look forward to continued momentum regarding research and it’s overlap with our other programmatic areas.

Total Grant Awards in 2019

Grants and Funding graphs

At the request of our Scientific Advisory Board, we are also pleased to report our research expenditures for the very first time in 2019:

  • Children’s Mercy: $1,707,929
  • University of Kansas Medical Center: $5,949,700

Top 10 Grants

Total direct costs

  1. TITLE: Midwestern Collaborative for Treating Obesity in Rural Primary Care
    PRINCIPAL INVESTIGATOR: Befort Cardador, Christie Ann
    SPONSOR: Patient-Centered Outcomes Research Institute
    START DATE: 01/01/15
    END DATE: 01/31/21
    DIRECTS: $7,841,908
    F & A: $2,232,234
    TOTAL: $10,074,142

  2. TITLE: Characterization of Sedentary Patterns and Cardiovascular Disease Rick Markers in Hispanics/ Latinos
    PRINCIPAL INVESTIGATOR: Carlson, Jordan
    SPONSOR: NIH
    START DATE: 07/1/19
    END DATE: 06/20/24
    DIRECTS: $5,639,963
    F & A: $490,146
    TOTAL: $6,130,109

  3. TITLE: The Promotion of Physica Activity for the Prevention of Alzheimer’s Disease in Adults with Down Syndrome
    PRINCIPAL INVESTIGATOR: Ptomey, Lauren Taylor
    SPONSOR: NIH
    START DATE: 08/01/19
    END DATE: 04/30/24
    DIRECTS: $2,398,207
    F & A: $1,245,921
    TOTAL: $3,644,128

  4. TITLE: Enhanced Mediterranean Diet for Alzheimer’s Disease Prevention
    PRINCIPAL INVESTIGATOR: Sullivan, Debra Kay
    SPONSOR: NIH
    START DATE: 09/30/18
    END DATE: 05/31/23
    DIRECTS: $2,311,779
    F & A: $1,205,583
    TOTAL: $3,517,362

  5. TITLE: Statins, Mitochondrial Function and Aerobic Capacity
    PRINCIPAL INVESTIGATOR: Thyfault, John P
    SPONSOR: NIH
    START DATE: 07/20/17
    END DATE: 06/30/22
    DIRECTS: $2,451,765
    F & A: $590,119
    TOTAL: $3,041,884

  6. TITLE: The safety and efficacy of megesterol as part of an outpatient feeding protocol for children with chronic medical conditions
    PRINCIPAL INVESTIGATOR: Davis, Ann Marjorie
    SPONSOR: NIH
    START DATE: 09/13/18
    END DATE: 06/30/23
    DIRECTS: $1,571,520
    F & A: $633,374
    TOTAL: $2,204,894

  7. TITLE: Rural Disparities in Pediatric Obesity: The iAmHealthy Intervention
    PRINCIPAL INVESTIGATOR: Davis, Ann Marjorie
    SPONSOR: NIH
    START DATE: 01/11/17
    END DATE: 11/30/21
    DIRECTS: $1,296,683
    F & A: $569,663
    TOTAL: $1,866,346

  8. TITLE: Aerobic Fitness, Mitochondrial Function, and Fatty Liver Disease
    PRINCIPAL INVESTIGATOR: Thyfault, John P
    SPONSOR: NIH
    START DATE: 07/01/19
    END DATE: 06/30/23
    DIRECTS: $1,336,983
    F & A: $528,993
    TOTAL: $1,865,976

  9. TITLE: Longitudinal Test of Adherence & Control in Kids New to T1 Diabetes & 5-9 Years Old
    PRINCIPAL INVESTIGATOR: Nelson, Eve-Lynn
    SPONSOR: NIH
    START DATE: 08/01/14
    END DATE: 07/31/20
    DIRECTS: $1,342,482
    F & A: $435,809
    TOTAL: $1,778,291

  10. TITLE: Comorbid Mood and Urogenital Disorders in Mice Following Neonatal Maternal Separation
    PRINCIPAL INVESTIGATOR: Carlsten Christianson, Julie Anna
    SPONSOR: NIH
    START DATE: 09/23/14
    END DATE: 07/31/20
    DIRECTS: $1,125,000
    F & A: $573,750
    TOTAL: $1,698,75

Top 18 Most Impactful & Representative Publications

  1. Allum, F., Hedman, Å. K., Shao, X., Cheung, W. A., Vijay, J., Guénard, F., Grundberg, E., … & Boulier, E. (2019). Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements. Nature communications, 10(1), 1–13. Impact Factor 11.878

  2. Mische Lawson, L. & Lisk, C. (2019). Feasibility Study of Perceived Exertion and Heart Rate of Children with ASD during Swimming. American Journal of Recreational Therapy, 18,(2), 29–37. Impact Factor 5.473

  3. Davis, A.M., Hanrahan, L.P., Bokov, A.F., Schlachter, S., Laroche, H.H., Waitman, L.R., GPC Height Weight Research Team. (2019). Patient Engagement and Attitudes toward Using the Electronic Medical Record for Medical Research: The 2015 Greater Plains Collaborative Health and Medical Research Family Survey. JMIR Res Protoc, 8(3), e11148. Impact Factor 4.945

  4. Rasu, R., Thelen, J., Agbor Bawa, W., Goggin, K., Bradley- Ewing, A., & Catley, D. (2019). Motivational Interviewing to encourage quit attempts among smokers not ready to quit: A trial based economic analysis. Nicotine and Tobacco Research. doi: 10.1093/ntr/ntz228. Impact Factor 4.609

  5. Fazino, T.L., Rohde, K., Sullivan, D.K. Hyper-palatable foods: Development of a quantitative definition and application to the US food system database. Obesity 27(11):1761–1768, 2019. Impact Factor 4.514

  6. Pelaez, C.A., Davis, J.W., Spilman, S.K., Guzzo, H.M., Wetjen K.M., Randell, K.A., Ortega, H.W., Pitcher, G.J., Kenardy, J., Ramirez MR. Who hurts more? A multicenter, prospective study of in-hospital opioid use in pediatric trauma patients in the Midwest. Journal of the American College of Surgeons. 2019. Online ahead of print. doi: 10.1016/j. jamcollsurg.2019.05.021. Impact Factor 4.450

  7. Clements, M.A., Schwandt, A., Donaghue, K.C., Millker, K., Lück, U., Couper, J.J., Foster, N., Schröder, C., Phelan, H., Maahs, D., Prinz, N., Craig, M. on behalf of the Australasian Diabetes Data Network (ADDN) Study Group, the T1D Exchange ClinicNetwork (T1DX), and the German/ Austrian/ Luxembourgian Diabetes-Patienten-Verlaufsdokumentation (DPV) initiative. Five heterogeneous HbA1ctrajectories from childhood to adulthood in youth with type 1 diabetes from three different continents – a group-based modeling approach. Pediatric Diabetes. Accepted for publication 8/6/2019. Impact Factor 4.267

  8. Masonbrink, A.R., Miller, M.K. Caring for Hospitalized Adolescents: Opportunities to Identify and Address Unmet Reproductive Health Needs. Journal of Adolescent Health 64 (2019) 689e690. Impact Factor 4.021

  9. Morris, E.M., Meers, G.M., Ruegsegger, G.N., Wankhade, U. D., Robinson, T., Koch, L.G., … & Thyfault, J.P. (2019). Intrinsic high aerobic capacity in male rats protects against dietinduced insulin resistance. Endocrinology, 160(5), 1179–1192. Impact Factor 3.961

  10. Kyler, K.E., Bettenhausen, J.L., Hall, M., Fraser, J.D., Sweeney, B. Trends in Volume and Utilization Outcomes in Adolescent Metabolic and Bariatric Surgery at Children’s Hospitals. J Adolesc Health. 2019 Sep;65(3):331–336. Impact Factor 3.612

  11. Connelly, M., Schanberg, L.E., Ardoin, S., Blakley, M., Carrasco, R., Chira, P., Hayward, K., Ibarra, M., Kimura, Y., Kingsbury, D.J., Klein-Gitelman, M.S., Lawson, E., & Stinson, J. (2019). Multi-site randomized clinical trial evaluating an online selfmanagement program for adolescents with Juvenile Idiopathic Arthritis. Journal of Pediatric Psychology, 44(3), 363–374. Impact factor 3.609

  12. Fazzino, T., Forbush, K., Sullivan, D., & Befort, C.A. (2019, May). A prospective study of alcohol use patterns and short-term weight change in college freshmen. Alcoholism: Clinical and Experimental Research, 43(5): 1016–1026. Impact Factor 3.235

  13. Timmers, I., Simons, L.E., Hernandez, J.M., McCracken, L.M., & Wallace, D.P. (2019). Parent psychological flexibility in the context of pediatric pain: Brief assessment and associations with parent behavior and child functioning. European Journal of Pain, 23, 1340–1350. doi: 10.1002/ejp.1403. Impact Factor 3.188

  14. McMahon, D.M., Burch, J.B., Youngstedt, S.D., Wirth, M.D., Hardin, J.W., Hurley, T.G., Blair, S.N., Hand, G.A., Shook, R. P., Drenowatz, C., Burgess, S., & Hebert, J.R. (2019). Relationships between chronotype, social jetlag, sleep, obesity and blood pressure in healthy young adults AU-McMahon, Daria M. Chronobiology International, 1–17.doi:10.1080/074205 28.2018.1563094. Impact Factor 2.56
  1. McCoin, C.S., Von Schulze, A., Allen, J., Fuller, K.N., Xia, Q., Koestler, D.C., … & Morris, E.M., Thyfault, J.P. (2019). Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. American Journal of Physiology- Endocrinology and Metabolism. Impact Factor 2.36

  2. Davis, A.M., Beaver, G., Dreyer Gillette, M., Nelson, E.L., Fleming, K., Swinburne Romine, R., Sullivan, D., Lee, R,. Pettee Gabriel, K., Dean, K., Murray, M., Faith, M. iAmHealthy: Rationale, design and application of a family-based mHealth pediatric obesity intervention for rural children. Contemporary Clinical Trials, 78, 20–26. Impact Factor 2.095

  3. Gibbs H.D., Bonenberger, H., Hull, H.R., Sullivan, D.K. and Gibson, C. Validity of an updated nutrition literacy assessment instrument with the new nutrition facts panel. (2019). In J Food Sciences. 29:1–6. Impact Factor 2.081

  4. Ha, O.R., Lim, S.L., Bruce, J.M., Bruce, A.S. (2019). Unhealthy foods taste better among children with lower self-control. Appetite 139: 84–89. Impact Factor 1.89